Science Highlights

Ma et al. PNAS (2024). Mavacamten stabilized myosin in response to inotropic interventions.

Jani et al. PNAS Nexus (2024). The structural and biochemical states of thick filament activation can be decoupled

Ma et al. PNAS (2023). Proteins structure and function in heart muscle

Jani et al. Circulation (2023) Thick Filament Inactivation in Human Heart Failure

Hessel et al. PNAS (2022). Titin force alters thick and thin filament protein connections

Ma et al. J Physio (2020). Relaxation at the Molecular Level

Padron et al. PNAS (2020). Interacting Head Motif (IHM) exists in vivo.

New Resource for the Muscle Diffraction Community

A Super-relaxed Myosin State to Offset Hypertrophic Cardiomyopathy