Publications in the last two years:
Mohran, S., McMillen, T. S., Mandrycky, C., Tu, A. Y., Kooiker, K. B., Qian, W., Neys, S., Osegueda, B., Moussavi-Harami, F., Irving, T. C., Regnier, M., & Ma, W. (2024). Calcium has a direct effect on thick filament activation in porcine myocardium. The Journal of general physiology, 156(11), e202413545.
Turner, K. L., Vander Top, B. J., Kooiker, K. B., Mohran, S., Mandrycky, C., McMillen, T., Regnier, M., Irving, T. C., Ma, W., & Tanner, B. C. W. (2024). The structural and functional effects of myosin regulatory light chain phosphorylation are amplified by increases in sarcomere length and [Ca2+]. The Journal of physiology, 10.1113/JP286802.
van den Berg, M., Shi, Z., Claassen, W. J., Hooijman, P., Lewis, C. T. A., Andersen, J. L., van der Pijl, R. J., Bogaards, S. J. P., Conijn, S., Peters, E. L., Begthel, L. P. L., Uijterwijk, B., Lindqvist, J., Langlais, P. R., Girbes, A. R. J., Stapel, S., Granzier, H., Campbell, K. S., Ma, W., Irving, T., … Ottenheijm, C. A. C. (2024). Super-relaxed myosins contribute to respiratory muscle hibernation in mechanically ventilated patients. Science translational medicine, 16(758), eadg3894.
Jiratrakanvong, J., Shao, J., Li, J., Menendez Alvarez, M., Li, X., Das, P., Nikseresht, G., Miskin, N., Huo, R., Nabon, J., Leduc, T., Zhang, E., Ma, W., Agam, G., & Irving, T. C. (2024). MuscleX: data analysis software for fiber diffraction patterns from muscle. Journal of synchrotron radiation, 31(Pt 5), 1401–1408
Kooiker, K., Gan, Q. F., Yu, M., Sa, N., Mohran, S., Cheng, Y., Flint, G., Neys, S., Gao, C., Nissen, D., McMillen, T., Asencio, A., Ma, W., Irving, T. C., Moussavi-Harami, F., & Regnier, M. (2024). Mechanisms of a novel regulatory light chain-dependent cardiac myosin inhibitor. The Journal of general physiology, 156(10), e202313503
Hessel, A. L., M. N. Kuehn, S. W. Han, W. Ma, T. C. Irving, B. A. Momb, T. Song, S. Sadayappan, W. A. Linke, and B. M. Palmer. (2024). Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure. Commun Biol 7(1):648.
Hessel, A. L., M. N. Kuehn, N. M. Engels, D. L. Nissen, J. K. Freundt, W. Ma, T. C. Irving, and W. A. Linke. (2024). Titin-Based Force Modulates Cardiac Thick and Thin Filaments. Circulation Research 134(8):1026-1028.
Hessel, A. L., N. M. Engels, M. N. Kuehn, D. Nissen, R. L. Sadler, W. Ma, T. C. Irving, W. A. Linke, and S. P. Harris. (2024). Myosin-binding protein C regulates the sarcomere lattice and stabilizes the OFF states of myosin heads. Nat Commun 15(1):2628.
Zhao, J., L. Qi, S. Yuan, T. C. Irving, and W. Ma. (2024). Differences in thick filament activation in fast rodent skeletal muscle and slow porcine cardiac muscle. The Journal of Physiology, https://doi.org/10.1113/JP286072.
Ma, W., Del Rio, C. L., Qi, L., Prodanovic, M., Mijailovich, S., Zambataro, C., Gong, H., Shimkunas, R., Gollapudi, S., Nag, S., & Irving, T. C. (2024). Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited in response to inotropic interventions. Proceedings of the National Academy of Sciences of the United States of America, 121(8), e2314914121.
Jani, V. P., Song, T., Gao, C., Gong, H., Sadayappan, S., Kass, D. A., Irving, T. C., & Ma, W. (2024). The structural OFF and ON states of myosin can be decoupled from the biochemical super- and disordered-relaxed states. PNAS nexus, 3(2), pgae039.
Rodriguez Garcia, M., Schmeckpeper, J., Landim-Vieira, M., Coscarella, I. L., Fang, X., Ma, W., Spran, P. A., Yuan, S., Qi, L., Kahmini, A. R., Shoemaker, M. B., Atkinson, J. B., Kekenes-Huskey, P. M., Irving, T. C., Chase, P. B., Knollmann, B. C., & Pinto, J. R. (2023). Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a Dual Myofilament Modulatory Role by Alpha-Actinin 2. International journal of molecular sciences, 24(19), 14572.
Ma, W., Lee, K. H., Delligatti, C. E., Davis, M. T., Zheng, Y., Gong, H., Kirk, J. A., Craig, R., & Irving, T. (2023). The structural and functional integrities of porcine myocardium are mostly preserved by cryopreservation. The Journal of general physiology, 155(9), e202313345.
Kooiker, K. B., Mohran, S., Turner, K. L., Ma, W., Martinson, A., Flint, G., Qi, L., Gao, C., Zheng, Y., McMillen, T. S., Mandrycky, C., Mahoney-Schaefer, M., Freeman, J. C., Costales Arenas, E. G., Tu, A. Y., Irving, T. C., Geeves, M. A., Tanner, B. C. W., Regnier, M., Davis, J., … Moussavi-Harami, F. (2023). Danicamtiv Increases Myosin Recruitment and Alters Cross-Bridge Cycling in Cardiac Muscle. Circulation research, 133(5), 430–443.
Jani, V., Aslam, M. I., Fenwick, A. J., Ma, W., Gong, H., Milburn, G., Nissen, D., Cubero Salazar, I. M., Hanselman, O., Mukherjee, M., Halushka, M. K., Margulies, K. B., Campbell, K. S., Irving, T. C., Kass, D. A., & Hsu, S. (2023). Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure With Pulmonary Hypertension. Circulation, 147(25), 1919–1932.
Landim-Vieira, M., Ma, W., Song, T., Rastegarpouyani, H., Gong, H., Coscarella, I. L., Bogaards, S. J. P., Conijn, S. P., Ottenheijm, C. A. C., Hwang, H. S., Papadaki, M., Knollmann, B. C., Sadayappan, S., Irving, T. C., Galkin, V. E., Chase, P. B., & Pinto, J. R. (2023). Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function. Proceedings of the National Academy of Sciences of the United States of America, 120(23), e2221244120.
Ma, W., McMillen, T. S., Childers, M. C., Gong, H., Regnier, M., & Irving, T. (2023). Structural OFF/ON transitions of myosin in relaxed porcine myocardium predict calcium-activated force. Proceedings of the National Academy of Sciences of the United States of America, 120(5), e2207615120.
For a complete list of publications:
MuscleX Lab 